{"id":57803,"date":"2026-02-27T06:00:00","date_gmt":"2026-02-27T05:00:00","guid":{"rendered":"https:\/\/trendsanita.it\/?p=57803"},"modified":"2026-02-26T20:32:57","modified_gmt":"2026-02-26T19:32:57","slug":"vaccines-3-0-and-the-100-days-mission","status":"publish","type":"post","link":"https:\/\/trendsanita.it\/en\/vaccines-3-0-and-the-100-days-mission\/","title":{"rendered":"Vaccines 3.0 and the \u201c100 Days Mission\u201d: Europe\u2019s New Health Sovereignty"},"content":{"rendered":"\n

The world of infectious diseases is evolving rapidly: in the last 40 years, we have faced eight major threats and three pandemics<\/strong>. Against this backdrop, the European #VaccinAction 2025 workshop<\/strong>, \u201cThe future of vaccine development: research, data, participation\u201d will focus on this issue .<\/a> In Brussels, he outlined a clear vision: science can no longer simply chase emergencies; it must learn to prevent them. One of the keynote speakers at the debate was Dr. Rita Carsetti, Senior Advisor at the Fondazione Biotecnopolo di Siena and President of the International Union of Immunological Societies (IUIS)<\/strong>. She was supported by the reflections of Cittadinanzattiva – Active Citizenship Network (ACN) <\/a>, which had brought together 16 partner organizations from 12 countries<\/strong> for the occasion on the need to put citizens back at the center of immunization policies.<\/p>\n\n\n\n

The rationale behind the \u201c100 Days Mission\u201d: saving eight million lives<\/h2>\n\n\n\n

The cornerstone of the new pandemic preparedness is the so-called \u201c100 Days Mission,\u201d a global goal supported by the G7, G20, and the World Health Organization<\/strong>. But why exactly 100 days? \u201cIt’s been calculated that in the early stages of a pandemic, not many people are infected; the exponential increase occurs after the first 100 days,\u201d explains Carsetti<\/strong>.<\/p>\n\n\n\n

It has been estimated that, during pandemics, the exponential increase in infections occurs after the first 100 days<\/p>\n\n\n\n

Scientific rationale is supported by dramatic data: if we had developed a vaccine within 100 days of sequencing SARS-CoV-2, approximately eight million lives globally would have been saved<\/strong>. To achieve this goal, research is currently working on so-called \u201cprototype pathogens<\/strong>.\u201d This involves building already-tested and functional \u201cbase\u201d vaccines, which simply require a change in the specific antigen, such as the Spike protein, to respond to a new threat, having already agreed on protocols and results with regulatory bodies in \u201cpeacetime.\u201d<\/p>\n\n\n\n

Reverse Vaccinology 3.0: AI as an Immunological Shortcut<\/h2>\n\n\n\n

The real technological leap forward is represented by Reverse Vaccinology 3.0, an approach that Carsetti calls a true shortcut<\/strong>. While version 2.0 began by analyzing survivors to isolate antibodies while already knowing the antigen, version 3.0 reverses the process thanks to AI.<\/p>\n\n\n

\n
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The European #VaccinAction 2025 workshop<\/figcaption><\/figure>\n<\/div>\n\n\n
<\/div>\n\n\n\n

\u201cToday, we can take the memory cells of those who survived a new virus, even without knowing what the protective antigen is,\u201d the immunologist explains. Through advanced models like AlphaFold 3, AI analyzes the structure of effective antibodies and \u201cpredicts\u201d the shape of the molecular lock (the antigen) into which they should fit<\/strong>. This process reduces years of laboratory trials to a few targeted experiments, allowing us to design mRNA or recombinant protein vaccines in record time. This technology is already yielding promising results against global threats like Monkeypox<\/strong>.<\/p>\n\n\n\n

The fight against the \u201csilent pandemic\u201d of AMR and bacterial linkage<\/h2>\n\n\n\n

The Siena Biotechnopole doesn’t just deal with viruses, but also addresses the crucial challenge of antibiotic resistance <\/strong>(AMR), defined as a \u201csilent pandemic\u201d that already causes five million deaths a year. Carsetti emphasizes that vaccines are the decisive weapon: \u201cIf you have a vaccine, you don’t need antibiotics because you won’t get the disease.\u201d<\/p>\n\n\n\n

Research has achieved extraordinary results against Shigella<\/em>, a bacterium that kills thousands of children, with 100% protection in experimental models. The approach against pan-resistant Klebsiella pneumoniae is innovative<\/em><\/strong>, based on the \u201cenchainment\u201d mechanism : <\/em>the selected antibodies do not simply bind to the bacterium, but \u201cglue\u201d it to its peers, preventing it from entering cells and causing sepsis. This method overcomes the limitations of older approaches, which often identified antibodies capable of binding to the target but incapable of neutralizing the disease.<\/p>\n\n\n\n

Siena Biotechnopole: The Hub for European Independence<\/h2>\n\n\n\n

In this landscape, Italy plays a central role with the Biotecnopolo of Siena<\/a>, a facility funded by the Italian government. The Biotecnopolo is also the coordinator of a European project designated as the European Vaccine Hub (EVH)<\/strong>, which is supported by the European agency HERA and aims to ensure the continent\u2019s autonomy in the development and production of vaccines for the prevention of future pandemics.<\/p>\n\n\n\n

\u201cEurope must be able to produce vaccines independently<\/strong>,\u201d Carsetti reiterated. The EVH acts as an ecosystem that covers the entire cycle: from antigen discovery to the production of batches for Phase 1 and 2 clinical trials, ensuring that innovation doesn’t remain locked away in laboratories but becomes a public resource ready for emergency approval.<\/p>\n\n\n\n

The human factor: transparency and active participation<\/h2>\n\n\n\n

Despite technological optimism, Dr. Carsetti warns that the greatest challenge remains environmental and social<\/strong>. \u201cPersonally, I believe climate change is the biggest problem,\u201d she states in the interview, linking deforestation and the movement of species like bats to the emergence of new viruses.<\/p>\n\n\n\n

Innovation must go hand in hand with patients\u2019 rights<\/p>\n\n\n\n

In this context, the #VaccinAction 2025 project, promoted by Active Citizenship Network (ACN), is crucial for sharing knowledge and rebuilding trust. Daniela Quaggia<\/strong>, Senior Project Manager for Cittadinanzattiva-Active Citizenship Network, emphasizes that innovation must go hand in hand with patient rights. \u201cThe greatest gap we see between research participants and organizers is the shift from ‘object of study’ to recognized partner<\/strong>,\u201d explains Quaggia.<\/p>\n\n\n\n

According to Cittadinanzattiva, data transparency is a powerful tool against vaccine hesitancy<\/strong>. \u201cSeeing your immunological data explained in the right context can be more convincing than any slogan,\u201d says Quaggia. Providing clear and understandable information isn’t just an act of courtesy, but a way to recognize the value of people’s role in science, transforming prevention into a conscious and tailored choice.<\/p>\n\n\n\n

The \u201cone hundred day race\u201d can only be won if the speed of technology is combined with a culture of participation, where citizens are no longer passive observers but active stakeholders in global health security.<\/p>\n\n\n

\n
\"\"<\/a><\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"

From the lessons of COVID-19 to the challenge of AI and the Siena Biotechnopole:
\nRita Carsetti outlines the strategy to stop pandemics before they start, while Daniela Quaggia highlights the central role of citizens as active partners in research<\/p>\n","protected":false},"author":4407,"featured_media":57805,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[544],"tags":[549,695],"rubrica":[],"speciale":[],"class_list":{"0":"post-57803","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-across-europe-en","8":"tag-europe-en","9":"tag-organisation"},"yoast_head":"\nVaccines 3.0 and the \u201c100 Days Mission\u201d: Europe\u2019s New Health Sovereignty<\/title>\n<meta name=\"description\" content=\"Rita Carsetti outlines the strategy to stop pandemics before they start, while Daniela Quaggia highlights the central role of citizens as active partners in research\" \/>\n<meta name=\"robots\" content=\"index, follow, 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